Browsing by Subject "BRUCELLA ABORTUS"

Now showing items 21-36 of 36

    • Epidemiology of bovine brucellosis in Costa Rica: Lessons learned from failures in the control of the disease 

      Hernández-Mora, Gabriela; Ruiz-Villalobos, Nazareth; Bonilla-Montoya, Roberto; Romero-Zúñiga, Juan José; Jiménez-Arias, Julio; González-Barrientos, Rocio; BARQUERO-CALVO, ELIAS; Chacón-Díaz, Carlos; Rojas, Norman; Chaves-Olarte, Esteban; Guzman-Verri, Caterina; Moreno, Edgardo (PLOS ONE, 2017-08-10)
      Brucellosis, caused by Brucella abortus is a major disease of cattle and a zoonosis. In order to estimate the bovine brucellosis prevalence in Costa Rica (CR), a total 765 herds (13078 bovines) from six regions of CR ...

    • Extensive Cell Envelope Modulation Is Associated with Virulence in Brucella abortus 

      Lamontagne, Julie; Butler, Heather; Chaves, Esteban; Hunter, Joanna; Schirm, Michael; Paquet, Caroline; Tian, Mei; Kearney, Paul; Hamaidi, Lyes; Chelsky, Danie; Moriyón, Ignacio; Moreno, Edgardo; Paramithiotis, Eustache (American Chemical Society, 2007-08-03)
      Brucella virulence is linked to components of the cell envelope and tightly connected to the function of the BvrR/BvrS sensory-regulatory system. To quantify the impact of BvrR/BvrS on cell envelope proteins, we performed ...

    • GTPases of the Rho subfamily are required for Brucella abortus internalization in nonprofessional phagocytes 

      Guzman-Verri, Caterina; Chaves-Olarte, Esteban; von Eichel-Streiber, Christoph; López-Goñi, Ignacio; Thelestam, Mónica; Arvidson, Staffan; Gorvel, Jean-Pierre; Moreno, Edgardo (The American Society for Biochemistry and Molecular Biology, Inc., 2001-11-30)
      Members of the genus Brucella are intracellular -Proteobacteria responsible for brucellosis, a chronic disease of humans and animals. Little is known about Brucella virulence mechanisms, but the abilities of these ...

    • Intracellular adaptation of Brucella abortus 

      Lamontagne, Julie; Forest, Anik; Marazzo, Elena; François, Denis; Butler, Heather; Michaud, Jean-François; Boucher, Lyne; Pedro, Ida; Villeneuve, Annie; Sitnikov, Dmitri; Trudel, Sylvie; Nassif, Najib; Boudjelt, Djamila; Tomaki, Fadi; Chaves-Olarte, Esteban; Guzman-Verri, Caterina; Brunet, Sylvain; Côté-Martin, Alexandra; Hunter, Joanna; Moreno, Edgardo; Paramithiotis, Eustache (Universidad Nacional, Costa Rica, 2009-03)
      Macrophages were infected with virulent B. abortus strain 2308 or attenuated strain 19. Intracellular bacteria were recovered at different times after infection and their proteomes compared. The virulent strain initially ...

    • N-formyl-perosamine surface homopolysaccharides hinder the recognition of Brucella abortus by mouse neutrophils 

      Mora-Cartín, Ricardo; Chacón-Díaz, Carlos; Gutiérrez-Jiménez, Cristina; Gurdián-Murillo, Stephany; Lomonte, Bruno; Chaves-Olarte, Esteban; BARQUERO-CALVO, ELIAS; Moreno, Edgardo (Universidad Nacional, Costa Rica, 2016-06)
      Brucella abortus is an intracellular pathogen of monocytes, macrophages, dendritic cells, and placental trophoblasts. This bacterium causes a chronic disease in bovines and in humans. In these hosts, the bacterium also ...

    • Neutrophils as Trojan Horse vehicles for Brucella abortus macrophage infection 

      Gutiérrez-Jiménez, Cristina; Mora-Cartín, Ricardo; Altamirano-Silva, Pamela; Chacón-Díaz, Carlos; Chaves-Olarte, Esteban; Moreno, Edgardo; BARQUERO-CALVO, ELIAS (Universidad Nacional, Costa Rica, 2019-05-07)
      Brucella abortus is a stealthy intracellular bacterial pathogen of animals and humans. This bacterium promotes the premature cell death of neutrophils (PMN) and resists the killing action of these leukocytes. B. abortus-infected ...

    • Neutrophils dampen adaptive immunity in Brucellosis 

      Mora-Cartín, Ricardo; Gutiérrez-Jiménez, Cristina; Alfaro-Alarcón, Alejandro; Chaves-Olarte, Esteban; Chacón-Díaz, Carlos; BARQUERO-CALVO, ELIAS; Moreno, Edgardo (American Society For Microbiology, 2019-04-23)
      Brucella organisms are intracellular stealth pathogens of animals and humans. The bacteria overcome the assault of innate immunity at early stages of an infection. Removal of polymorphonuclear neutrophils (PMNs) at the ...

    • Neutrophils exert a suppressive effect on Th1 responses to intracellular pathogen Brucella abortus 

      BARQUERO-CALVO, ELIAS; Martirosyan, Anna; Ordoñez-Rueda, Diana; Arce-Gorvel, Vilma; Alfaro-Alarcón, Alejandro; Lepidi, Hubert; Malissen, Bernard; Malissen, Marie; Gorvel, Jean-Pierre; Moreno, Edgardo (PLoS Pathogens, 2013-02-14)
      Polymorphonuclear neutrophils (PMNs) are the first line of defense against microbial pathogens. In addition to their role in innate immunity, PMNs may also regulate events related to adaptive immunity. To investigate the ...

    • Persistence of Brucella abortus in the bone marrow of infected mice 

      Gutiérrez-Jiménez, Cristina; HYSENAJ, LISIENA; Alfaro-Alarcón, Alejandro; Mora-Cartín, Ricardo; Gorvel, Jean-Pierre; Arce-Gorvel, Vilma; Moreno, Edgardo; BARQUERO-CALVO, ELIAS (Journal of Immunology Research, 2018-12-03)
      Brucellosis is a zoonotic bacterial infection that may persist for long periods causing relapses in antibiotic-treated patients. The ability of Brucella to develop chronic infections is linked to their capacity to invade ...

    • Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis 

      Suárez-Esquivel, Marcela; Henández-Mora, Gabriela; Ruiz-Villalobos, Nazareth; BARQUERO-CALVO, ELIAS; Chacón-Díaz, Carlos; LadnerI, JasonT.; Oviedo-Sánchez, Gerardo; Foster, JeffreyT.; Rojas-Campos, Norman; Chaves-Olarte, Esteban; Thomson, Nicholas; Moreno, Edgardo; Guzman-Verri, Caterina (PLOS Neglected Tropical Diseases, 2020-04-14)
      Brucellosis, caused by Brucella abortus, is a major disease of cattle and humans worldwide distributed. Eradication and control of the disease has been difficult in Central and South America, Central Asia, the Mediterranean ...

    • Platelet depletion does not alter the course of Brucella abortus infection in vivo 

      Arias-Gomez, Berny; Fonseca-Munoz, Roger; Alfaro-Alarcon, Alejandro; Chacon-Díaz, Carlos; Moreno, Edgardo; Rucavado, Alexandra; BARQUERO-CALVO, ELIAS (Elsevier, 2022-02-23)
      Brucellosis is a bacterial disease of animals and a zoonotic infection. Thrombocytopenia is a common outcome in long-lasting brucellosis in humans. Likewise, ex vivo experiments have shown that platelets may play a role ...

    • Public 2308W annotation 

      Suárez-Esquivel, Marcela; Ruiz-Villalobos, Nazareth; Castillo Zeledon, Amanda; Jiménez-Rojas, César; Roop II, R. Martin; Comerci, Diego J.; BARQUERO-CALVO, ELIAS; Chacón-Díaz, Carlos; Caswell, Clayton C.; Baker, Kate; Chaves-Olarte, Esteban; Thomson, Nicholas; Moreno, Edgardo; LETESSON, Jean-Jacques; De Bolle, Xavier; Guzman-Verri, Caterina (Universidad Nacional, Costa Rica, 2016-09-29)
      This is an editable version of B. abortus 2308W. The aim of this document is to provide a simple mechanism for updates in genes annotation.

    • Purification of intracellular bacteria: isolation of viable Brucella abortus from host cells 

      Chaves-Olarte, Esteban; Altamirano-Silva, Pamela; Guzman-Verri, Caterina; Moreno, Edgardo (Springer Science, Business Media Nueva York, 2014, 2014)
      The pathogenesis of brucellosis depends on the ability of bacteria from the genus Brucella to invade and replicate within animal cells. To understand the molecular pathways used by Brucella spp. to reach its intracellular ...

    • The differential interaction of brucella and ochrobactrum with innate immunity reveals traits related to the evolution of stealthy pathogens 

      BARQUERO-CALVO, ELIAS; Conde-Álvarez, Raquel; Chacón-Díaz, Carlos; Quesada-Lobo, LucÍa; Martirosyan, Anna; Guzman-Verri, Caterina; Iriarte, Maite; Manček Keber, Mateja; Jerala, Roman; Gorvel, Jean-Pierre; Moriyon, Ignacio; Moreno, Edgardo; Chaves-Olarte, Esteban (PLOS ONE, 2009-06-16)
      Background: During evolution, innate immunity has been tuned to recognize pathogen-associated molecular patterns. However, some a-Proteobacteria are stealthy intracellular pathogens not readily detected by this system. ...

    • The two-component system BvrR BvrS essential for Brucella abortus virulence regulates the expression of outer membrane proteins with counterparts in members of the Rhizobiaceae 

      Guzman-Verri, Caterina; Manterola, Lorea; Sola-Landa, Alberto; Parra, A.; Cloeckaert, A.; GARIN, Jérôme; Gorvel, Jean-Pierre; Moriyon, Ignacio; Moreno, Edgardo; López-Goñi, Ignacio (Proceedings of the National Academy of Sciences, 2002-09-17)
      The Brucella BvrR/BvrS two-component regulatory system is homologous to the ChvI/ChvG systems of Sinorhizobium meliloti and Agrobacterium tumefaciens necessary for endosymbiosis and pathogenicity in plants. BvrR/BvrS ...

    • The two-component system BvrR/BvrS regulates the expression of the Type IV secretion system VirB in Brucella abortus 

      Martínez-Núñez, Carola; Altamirano-Silva, Pamela; Alvarado-Guillén, Francisco; Moreno, Edgardo; Guzman-Verri, Caterina; Chaves-Olarte, Esteban (American Society for Microbiology, 2010-11)
      The pathogenesis of Brucella is related to the ability to multiply intracellularly, an event controlled by the two-component system BvrR/BvrS (TCS BvrRS) and the type IV secretion machinery VirB (T4SS VirB). We have ...