Browsing by Subject "BRUCELLA"
Now showing items 1-20 of 60
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A sensor histidine kinase from a plant-endosymbiont bacterium restores the virulence of a mammalian intracellular pathogen
(Elsevier, 2023-11-08)Alphaproteobacteria include organisms living in close association with plants or animals. This interaction relies partly on orthologous two-component regulatory systems (TCS), with sensor and regulator proteins modulating ... -
Activation of Rho and Rab GTPases dissociates Brucella abortus internalization from intracellular trafficking
(Blackwell Science, 2002-10-04)Brucella abortus is an intracellular pathogen that relies on unconventional virulence factors to infect hosts. In non-professional phagocytes, Rho GTPasesactivation by the Escherichia coli cytotoxic necrotiz ing factor ... -
Bacterial counts in spleen
(Bio-protocol, 2013-11-05)Bacterial loads can be determined as colony forming units (CFU) at any point of the infection by culturing spleen homogenates on agar plates. This is a reliable method for comparing the kinetics of infection in various ... -
Brucella abortus ornithine lipids are dispensable outer membrane components devoid of a marked pathogen-associated molecular pattern
(PLoS One, 2011-01-07)The brucellae are a-Proteobacteria facultative intracellular parasites that cause an important zoonosis. These bacteria escape early detection by innate immunity, an ability associated to the absence of marked pathogen-associated ... -
Brucella abortus senses the intracellular environment through the BvrR/Bvrs two-component system, which allows B. abortus to adapt to its replicative nich
(American Society for Microbiology., 2018-01-16)Brucella abortus is a facultative extracellular-intracellular pathogen belonging to a group of Alphaproteobacteria that establishes close interactions with animal cells. This bacterium enters host cells in a membrane-bound ... -
Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection
(PLOS ONE, 2007-07-18)Background. To unravel the strategy by which Brucella abortus establishes chronic infections, we explored its early interaction with innate immunity. Methodology/Principal Findings. Brucella did not induce proinflammatory ... -
Brucella ceti and brucellosis in cetaceans
(Frontiers in cellular and infection microbiology, 2012-02-06)Since the first case of brucellosis detected in a dolphin aborted fetus, an increasing number of Brucella ceti isolates has been reported in members of the two suborders of cetaceans: Mysticeti and Odontoceti. Serological ... -
Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum
(The Rockefeller University Press, 2003-01-18)The intracellular pathogen Brucella is the causative agent of brucellosis, a worldwide zoonosis that affects mammals, including humans. Essential to Brucella virulence is its ability to survive and replicate inside host ... -
Brucella genetic variability in wildlife marine mammals populations relates to host preference and ocean distribution
(Oxford University Press on behalf of the Society for Molecular Biology and Evolution, 2017-07-20)Intracellular bacterial pathogens probably arose when their ancestor adapted from a free-living environment to an intracellular one, leading to clonal bacteria with smaller genomes and less sources of genetic plasticity. ... -
Brucella genomics: macro and micro evolution
(MDPI AG, 2020-10-20)Brucella organisms are responsible for one of the most widespread bacterial zoonoses, named brucellosis. The disease affects several species of animals, including humans. One of the most intriguing aspects of the brucellae ... -
Brucella melitensis: a nasty bug with hidden credentials for virulence
(The National Academy of Sciences, 2002-01-08)On September 23, 1905, a cargo carrying 60 goats from Malta arrived in New York. The herd was kept in quarantine because of several deaths that occurred during the journey. Crewmen, an agent from the U.S. Bureau of Animal ... -
Brucella sp. sequence‑type 27 associated with abortion in dwarf sperm whale Kogia sima
(Springer Link, 2021-05-18)A dwarf sperm whale Kogia sima stranded alive along the Central Pacifc Coast of Costa Rica. The whale, handled by tourists and local inhabitants, was weak, had buoyancy difculties, and eventually aborted and died, showing ... -
Brucella-Salmonella lipopolysaccharide chimeras are less permeable to hydrophobic probes and more sensitive to cationic peptides and EDTA than are their native Brucella sp. counterparts
(American Society for Microbiology, 1996-08-12)A rough (R) Brucella abortus 45/20 mutant was more sensitive to the bactericidal activity of polymyxin B and lactoferricin B than was its smooth (S) counterpart but considerably more resistant than Salmonella montevideo. ... -
Brucellosis in mammals of Costa Rica: an epidemiological survey
(PLOS ONE, 2017-08-09)La brucelosis ha sido una enfermedad endémica del ganado y los seres humanos en Costa Rica desde principios del siglo XX. Sin embargo, no se ha reportado brucelosis en ovejas, cabras, cerdos, búfalos de agua, caballos y ... -
Brucellosis in mammals of Costa Rica: An epidemiological survey
(PLOS ONE, 2017-08-09)Brucellosis has been an endemic disease of cattle and humans in Costa Rica since the beginning of XX century. However, brucellosis in sheep, goats, pigs, water buffaloes, horses and cetaceans, has not been reported in ... -
BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence
(American Society for Microbiology, 2007-07-30)The Brucella abortus two-component regulatory system BvrR/BvrS controls the expression of outer membrane proteins (Omp) Omp3a (Omp25) and Omp3b (Omp22). Disruption of bvrS or bvrR generates avirulent mutants with altered ... -
Caracterización de la región promotora del gen omp25 de Brucella abortus.
(Universidad Nacional, Costa Rica, 2010)La brucelosis es una enfermedad zoonótica, producida por bacterias del género Brucella. Muchos de los mecanismos que utiliza esta bacteria para invadir y replicarse en las células no se comprenden. Sin embargo, las ... -
Caracterización fenotípica de aislamientos de Brucella sp. obtenidos a partir de murciélagos (Desmodus rotundus) en Piedras Blancas, Puntarenas, Costa Rica
(Universidad Nacional, Costa Rica, 2024)Brucella es un género de bacterias responsable de causar brucelosis, una enfermedad zoonótica distribuida en el mundo. Las brucelas causan problemas reproductivos en animales domésticos y silvestres e infecciones ... -
Characterization of Brucella abortus and Brucella melitensis native haptens as outer membrane O-type polysaccharides independent from the smooth lipopolysaccharide
(American Society for Microbiology, 1996)Brucella native haptens (NHs) extracted with hot water from smooth (S)- type B. abortus and B. melitensis were purified to high levels of serological activity and compared with the polysaccharide obtained by acid hydrolysis ... -
Characterization of Brucella abortus lipopolysaccharide macrodomains as mega rafts
(Blackwell Science, 2005-09-28)The lipopolysaccharides (LPS) of intracellular Proteobacteria such as Brucella, Chlamydia, Legionella and Rickettsia, have properties distinct from enterobacterial LPSs. These properties include deficient LPS induction of ...
