Browsing by Subject "IRBESARTAN"

Now showing items 1-2 of 2

    • Irbesartan desmotropes: Solid-state characterization, thermodynamic study and dissolution properties 

      Araya Sibaja, Andrea Mariela; Campos, Carlos Eduardo de; Fandaruff, Cinira; Jose-Roberto, Vega-Baudrit; Guillen-Girón, Teodolito; Navarro-Hoyos, Mirtha; Cuffini, Silvia Lucia (Xi'an Jiaotong University, 2019-07-10)
      Irbesartan (IBS) is a tetrazole derivative and antihypertensive drug that has two interconvertible structures, 1H- and 2H-tautomers. The difference between them lies in the protonation of the tetrazole ring. In the ...

    • The effect of solution environment and the electrostatic factor on the crystallisation of desmotropes of irbesartan 

      Araya, Andrea; Urgelles, Mariola; Vásquez Castro, Felipe; Vargas-Huertas, Felipe; Jose-Roberto, Vega-Baudrit; Guillen-Girón, Teodolito; Navarro-Hoyos, Mirtha; Cuffini, Silvia Lucia (Royal Society of Chemistry, 2019)
      The experimental conditions necessary for stabilising irbesartan (IBS) tautomers in solution and selectively obtaining the desmotropic crystal forms are presented herein. 1H and 2H tautomers were stabilized in specific ...