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Emergence of an outbreak-associated Clostridium difficile variant with increased virulence
(Journal of Clinical Microbiology, 2015-04-23)
The prevalence of Clostridium difficile infections has increased due to the emergence of epidemic variants from diverse genetic lineages. Here we describe the emergence of a novel variant during an outbreak in a Costa Rican ...
In vivo animal models confrm an increased virulence potential and pathogenicity of the NAP1/RT027/ST01 genotype within the Clostridium difcile MLST Clade 2
(BioMed Central, 2020-09-22)
Background: Based on MLST analyses the global population of C. difcile is distributed in eight clades, of which
Clade 2 includes the “hypervirulent” NAP1/RT027/ST01 strain along with various unexplored sequence types ...