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Determination of streptomycin and doxycycline using LC/MS towards an effective treatment against an experimental Brucella abortus infection in mice
(Elsevier B.V, 2022-02-25)
Herein we described a versatile liquid chromatographic method for detection and quantification of the total
levels of two antimicrobials [i.e., streptomycin (STM) and doxycycline (DOX)], in mice plasma and selected
tissues, ...
Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes
(American Society for Microbiology, 1988-09-01)
Brucella abortus is an intracellular pathogen that replicates within a membrane-bounded compartment. In
this study, we have examined the intracellular pathway of the virulent B. abortus strain 2308 (S2308) and the
attenuated ...
Brucella abortus lipopolysaccharide in murine peritoneal macrophages acts as a down-regulator of T cell activation
(The American Association of Immunologists, Inc., 2000)
Macrophages play a central role in host immune responses against pathogens by acting as both professional phagocytic cells and
as fully competent APCs. We report here that the LPS from the facultative intracellular ...
MyD88, but not Toll-Like receptors 4 and 2, Is required for efficient clearance of Brucella abortus
(American Society for Microbiology, 2005-08)
It is not clear how the host initially recognizes and responds to infection by gram-negative pathogenic
Brucella spp. It was previously shown (D. S. Weiss, B. Raupach, K. Takeda, S. Akira, and A. Zychlinsky, J.
Immunol. ...