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A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence
(Blackwell Science, 1998-04-08)
Two mutants showing increased sensitivity to polycations and surfactants were obtained by transposon mutagenesis of virulent Brucella abortus 2308 Nal(r). These mutants showed no obvious in vitro growth defects and produced ...
Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum
(The Rockefeller University Press, 2003-01-18)
The intracellular pathogen Brucella is the causative agent of brucellosis, a worldwide zoonosis
that affects mammals, including humans. Essential to Brucella virulence is its ability to survive and
replicate inside host ...
Brucella abortus lipopolysaccharide in murine peritoneal macrophages acts as a down-regulator of T cell activation
(The American Association of Immunologists, Inc., 2000)
Macrophages play a central role in host immune responses against pathogens by acting as both professional phagocytic cells and
as fully competent APCs. We report here that the LPS from the facultative intracellular ...
Brucella-Salmonella lipopolysaccharide chimeras are less permeable to hydrophobic probes and more sensitive to cationic peptides and EDTA than are their native Brucella sp. counterparts
(American Society for Microbiology, 1996-08-12)
A rough (R) Brucella abortus 45/20 mutant was more sensitive to the bactericidal activity of polymyxin B and lactoferricin B than was its smooth (S) counterpart but considerably more resistant than Salmonella montevideo. ...
Characterization of Brucella abortus lipopolysaccharide macrodomains as mega rafts
(Blackwell Science, 2005-09-28)
The lipopolysaccharides (LPS) of intracellular Proteobacteria such as Brucella, Chlamydia, Legionella and Rickettsia, have properties distinct from enterobacterial LPSs. These properties include deficient LPS induction of ...
Pathogenicity and its implications in Taxonomy: The Brucella and Ochrobactrum Case
(MDPI, 2022)
The intracellular pathogens of the genus Brucella are phylogenetically close to Ochrobac-
trum, a diverse group of free-living bacteria with a few species occasionally infecting medically
compromised patients. A group ...