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Brucella neotomae infection in humans, Costa Rica
(Emerging Infectious Diseases, 2017-06)
Several species of Brucella are known to be zoonotic, but B. neotomae infection has been thought to be limited to wood rats. In 2008 and 2011, however, B. neotomae was isolated from cerebrospinal fluid of 2 men with ...
Depletion of complement enhances the clearance of Brucella abortus in mice
(American Society for Microbiology, 2018-08-06)
Brucellosis is a bacterial disease of animals and humans. Brucella abortus barely activates the innate immune system at the onset of infection, and this bacterium is resistant to the microbicidal action of complement. Since ...
Brucella abortus strain 2308 Wisconsin genome: Importance of the definition of reference strains
(Frontiers in Microbiology, 2016-09-29)
La brucelosis es una enfermedad infecciosa bacteriana que afecta a una amplia gama de mamíferos y una zoonosis desatendida causada por especies del género genéticamente homogéneo Brucella. Como en la mayoría de los estudios ...
Brucella abortus induces the premature death of human neutrophils through the action of Its lipopolysaccharide
(PLoS Pathogens, 2015-05-06)
Most bacterial infections induce the activation of polymorphonuclear neutrophils (PMNs), enhance their microbicidal function, and promote the survival of these leukocytes for protracted periods of time. Brucella abortus ...
Neutrophils dampen adaptive immunity in Brucellosis
(American Society For Microbiology, 2019-04-23)
Brucella organisms are intracellular stealth pathogens of animals and humans. The bacteria overcome the assault of innate immunity at early stages of an infection. Removal of polymorphonuclear neutrophils (PMNs) at the ...
Neutrophils as Trojan Horse vehicles for Brucella abortus macrophage infection
(Universidad Nacional, Costa Rica, 2019-05-07)
Brucella abortus is a stealthy intracellular bacterial pathogen of animals and humans. This bacterium promotes the premature cell death of neutrophils (PMN) and resists the killing action of these leukocytes. B. abortus-infected ...
Brucellosis caused by the wood rat pathogen Brucella Neotomae: two case reports
(Journal of Medical Case Reports, 2017-12-19)
Background: Brucellosis is a chronic bacterial disease caused by members of the genus Brucella. Among the classical species stands Brucella neotomae, until now, a pathogen limited to wood rats. However, we have identified ...
Brucella canis is an intracellular pathogen that induces a lower proinflammatory response than smooth zoonotic counterparts
(Infection and Immunity, 2015-09-29)
Canine brucellosis caused by Brucella canis is a disease of dogs and a zoonotic risk. B. canis harbors most of the virulence determinants defined for the genus, but its pathogenic strategy remains unclear since it has not ...
N-formyl-perosamine surface homopolysaccharides hinder the recognition of Brucella abortus by mouse neutrophils
(Universidad Nacional, Costa Rica, 2016-06)
Brucella abortus is an intracellular pathogen of monocytes, macrophages, dendritic cells, and placental trophoblasts. This bacterium causes a chronic disease in bovines and in humans. In these hosts, the bacterium also ...
The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition
(PLoS Pathogens, 2012-05-10)
Innate immunity recognizes bacterial molecules bearing pathogen-associated molecular patterns to launch inflammatory responses leading to the activation of adaptive immunity. However, the lipopolysaccharide (LPS) of the ...