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Platelet depletion does not alter the course of Brucella abortus infection in vivo
(Elsevier, 2022-02-23)
Brucellosis is a bacterial disease of animals and a zoonotic infection. Thrombocytopenia is a common outcome in
long-lasting brucellosis in humans. Likewise, ex vivo experiments have shown that platelets may play a role ...
The regulon of Brucella abortus two- component system BvrR/BvrS reveals the coordination of metabolic pathways required for intracellular life
(PLOS ONE, 2022-09-21)
Brucella abortus is a facultative intracellular pathogen causing a severe zoonotic disease
worldwide. The two-component regulatory system (TCS) BvrR/BvrS of B. abortus is con-
served in members of the Alphaproteobacteria ...
Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis
(PLOS Neglected Tropical Diseases, 2020-04-14)
Brucellosis, caused by Brucella abortus, is a major disease of cattle and humans worldwide distributed. Eradication and control of the disease has been difficult in Central and South America, Central Asia, the Mediterranean ...
Pathogenicity and its implications in Taxonomy: The Brucella and Ochrobactrum Case
(MDPI, 2022)
The intracellular pathogens of the genus Brucella are phylogenetically close to Ochrobac-
trum, a diverse group of free-living bacteria with a few species occasionally infecting medically
compromised patients. A group ...
A bvrR/bvrS Non-Polar Brucella abortus Mutant Confirms the Role of the Two-Component System BvrR/BvrS in Virulence and Membrane Integrity
(MDPI, 2023-08-05)
Brucella abortus is a bacterial pathogen causing bovine brucellosis worldwide. This facultative extracellular–intracellular pathogen can be transmitted to humans, leading to a zoonotic disease.
The disease remains a public ...
Virulent Brucella nosferati infecting Desmodus rotundus has emerging potential due to the broad foraging range of its bat host for humans and wild and domestic animals
(American Society for Microbiology, 2023-07-05)
Desmodus rotundus, vampire bats, transmit dangerous infections, and
brucellosis is a hazardous zoonotic disease, two adversities that coexist in the subtropical
and tropical areas of the American continent. Here, we ...
Phenotypes controlled by the Brucella abortus two component system BvrR/BvrS are differentially impacted by BvrR phosphorylation
(Frontiers Media S.A, 2023-05-10)
Brucella abortus is a zoonotic pathogen whose virulence depends on its ability to survive intracellularly at the endoplasmic reticulum derived compartment. The two-component system BvrR/BvrS (BvrRS) is essential for ...
The Brucella abortus two-component system response regulator BvrR binds to three DNA regulatory boxes in the upstream region of omp25
(Frontiers Media S.A, 2023-09-14)
Brucella abortus is a facultative extracellular-intracellular bacterial zoonotic pathogen worldwide. It is also a major cause of abortion in bovines, generating economic losses. The two-component regulatory system BvrR/BvrS ...
If You're Not Confused, You're Not Paying Attention: Ochrobactrum Is Not Brucella
(American Society for Microbiology, 2023-07-03)
Bacteria of the genus Brucella are facultative intracellular parasites that cause brucellosis, a severe animal and human disease. Recently, a group of taxonomists merged the brucellae with the primarily free-living, ...
A sensor histidine kinase from a plant-endosymbiont bacterium restores the virulence of a mammalian intracellular pathogen
(Elsevier, 2023-11-08)
Alphaproteobacteria include organisms living in close association with plants or animals. This interaction relies partly on orthologous two-component regulatory systems (TCS), with sensor and regulator proteins modulating ...