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Depletion of complement enhances the clearance of Brucella abortus in mice
(American Society for Microbiology, 2018-08-06)
Brucellosis is a bacterial disease of animals and humans. Brucella abortus barely activates the innate immune system at the onset of infection, and this bacterium is resistant to the microbicidal action of complement. Since ...
Neutrophils dampen adaptive immunity in Brucellosis
(American Society For Microbiology, 2019-04-23)
Brucella organisms are intracellular stealth pathogens of animals and humans. The bacteria overcome the assault of innate immunity at early stages of an infection. Removal of polymorphonuclear neutrophils (PMNs) at the ...
Persistence of Brucella abortus in the bone marrow of infected mice
(Journal of Immunology Research, 2018-12-03)
Brucellosis is a zoonotic bacterial infection that may persist for long periods causing relapses in antibiotic-treated patients. The ability of Brucella to develop chronic infections is linked to their capacity to invade ...
Brucella canis is an intracellular pathogen that induces a lower proinflammatory response than smooth zoonotic counterparts
(Infection and Immunity, 2015-09-29)
Canine brucellosis caused by Brucella canis is a disease of dogs and a zoonotic risk. B. canis harbors most of the virulence determinants defined for the genus, but its pathogenic strategy remains unclear since it has not ...
Neutrophils exert a suppressive effect on Th1 responses to intracellular pathogen Brucella abortus
(PLoS Pathogens, 2013-02-14)
Polymorphonuclear neutrophils (PMNs) are the first line of defense against microbial pathogens. In addition to their role in innate immunity, PMNs may also regulate events related to adaptive immunity. To investigate the ...