Browsing by Subject "BRUCELOSIS"
Now showing items 1-20 of 95
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A bvrR/bvrS Non-Polar Brucella abortus Mutant Confirms the Role of the Two-Component System BvrR/BvrS in Virulence and Membrane Integrity
(MDPI, 2023-08-05)Brucella abortus is a bacterial pathogen causing bovine brucellosis worldwide. This facultative extracellular–intracellular pathogen can be transmitted to humans, leading to a zoonotic disease. The disease remains a public ... -
A sensor histidine kinase from a plant-endosymbiont bacterium restores the virulence of a mammalian intracellular pathogen
(Elsevier, 2023-11-08)Alphaproteobacteria include organisms living in close association with plants or animals. This interaction relies partly on orthologous two-component regulatory systems (TCS), with sensor and regulator proteins modulating ... -
A Sinorhizobium meliloti and Agrobacterium tumefaciens ExoR ortholog is not crucial for Brucella abortus virulence
(PLOS ONE, 2021-08-13)Brucella is a facultative extracellular-intracellular pathogen that belongs to the Alphaproteo- bacteria class. Precise sensing of environmental changes and a proper response mediated by a gene expression regulatory ... -
A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence
(Blackwell Science, 1998-04-08)Two mutants showing increased sensitivity to polycations and surfactants were obtained by transposon mutagenesis of virulent Brucella abortus 2308 Nal(r). These mutants showed no obvious in vitro growth defects and produced ... -
Activation of Rho and Rab GTPases dissociates Brucella abortus internalization from intracellular trafficking
(Blackwell Science, 2002-10-04)Brucella abortus is an intracellular pathogen that relies on unconventional virulence factors to infect hosts. In non-professional phagocytes, Rho GTPasesactivation by the Escherichia coli cytotoxic necrotiz ing factor ... -
Age and Sexual Maturity Estimation of Stranded Striped Dolphins, Stenella coeruleoalba, Infected with Brucella ceti
(MDPI, 2022-10-31)Age parameters in cetaceans allow examining conservation and studying individuals with growth affection. The age and sexual maturity of 51 stranded Stenella coeruleoalba striped dolphins from the Eastern Tropical Pacific ... -
Applying One Health to understand brucellosis biology
(Microbiology Society UKCongreso de la Sociedad de Microbiología del Reino Unido, 2019-04-08)Members of the Brucella genus, are facultative extracellular intracellular zoonotic bacteria that cause reproductive disease in animals. The different species show strong host preference in spite of sharing 96-98% similarity ... -
Bacterial counts in spleen
(Bio-protocol, 2013-11-05)Bacterial loads can be determined as colony forming units (CFU) at any point of the infection by culturing spleen homogenates on agar plates. This is a reliable method for comparing the kinetics of infection in various ... -
Brucella abortus induces the premature death of human neutrophils through the action of Its lipopolysaccharide
(PLoS Pathogens, 2015-05-06)Most bacterial infections induce the activation of polymorphonuclear neutrophils (PMNs), enhance their microbicidal function, and promote the survival of these leukocytes for protracted periods of time. Brucella abortus ... -
Brucella abortus lipopolysaccharide in murine peritoneal macrophages acts as a down-regulator of T cell activation
(The American Association of Immunologists, Inc., 2000)Macrophages play a central role in host immune responses against pathogens by acting as both professional phagocytic cells and as fully competent APCs. We report here that the LPS from the facultative intracellular ... -
Brucella abortus ornithine lipids are dispensable outer membrane components devoid of a marked pathogen-associated molecular pattern
(PLoS One, 2011-01-07)The brucellae are a-Proteobacteria facultative intracellular parasites that cause an important zoonosis. These bacteria escape early detection by innate immunity, an ability associated to the absence of marked pathogen-associated ... -
Brucella abortus S19 GFP-tagged vaccine allows the serological identification of vaccinated cattle
(PLOS ONE, 2021-11-22)Bovine brucellosis induces abortion in cows, produces important economic losses, and causes a widely distributed zoonosis. Its eradication was achieved in several countries after sustained vaccination with the live ... -
Brucella abortus senses the intracellular environment through the BvrR/Bvrs two-component system, which allows B. abortus to adapt to its replicative nich
(American Society for Microbiology., 2018-01-16)Brucella abortus is a facultative extracellular-intracellular pathogen belonging to a group of Alphaproteobacteria that establishes close interactions with animal cells. This bacterium enters host cells in a membrane-bound ... -
Brucella abortus strain 2308 Wisconsin genome: Importance of the definition of reference strains
(Frontiers in Microbiology, 2016-09-29)La brucelosis es una enfermedad infecciosa bacteriana que afecta a una amplia gama de mamíferos y una zoonosis desatendida causada por especies del género genéticamente homogéneo Brucella. Como en la mayoría de los estudios ... -
Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes
(American Society for Microbiology, 1988-09-01)Brucella abortus is an intracellular pathogen that replicates within a membrane-bounded compartment. In this study, we have examined the intracellular pathway of the virulent B. abortus strain 2308 (S2308) and the attenuated ... -
Brucella abortus uses a stealthy strategy to avoid activation of the innate immune system during the onset of infection
(PLOS ONE, 2007-07-18)Background. To unravel the strategy by which Brucella abortus establishes chronic infections, we explored its early interaction with innate immunity. Methodology/Principal Findings. Brucella did not induce proinflammatory ... -
Brucella canis is an intracellular pathogen that induces a lower proinflammatory response than smooth zoonotic counterparts
(Infection and Immunity, 2015-09-29)Canine brucellosis caused by Brucella canis is a disease of dogs and a zoonotic risk. B. canis harbors most of the virulence determinants defined for the genus, but its pathogenic strategy remains unclear since it has not ... -
Brucella ceti and brucellosis in cetaceans
(Frontiers in cellular and infection microbiology, 2012-02-06)Since the first case of brucellosis detected in a dolphin aborted fetus, an increasing number of Brucella ceti isolates has been reported in members of the two suborders of cetaceans: Mysticeti and Odontoceti. Serological ... -
Brucella ceti infection in dolphins from the Western Mediterranean sea
(Frontiers in cellular and infection microbiology, 2012)Background: Brucella ceti infections have been increasingly reported in cetaceans. Brucellosis in these animals is associated with meningoencephalitis, abortion, discospondylitis', subcutaneous abscesses, endometritis and ... -
Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum
(The Rockefeller University Press, 2003-01-18)The intracellular pathogen Brucella is the causative agent of brucellosis, a worldwide zoonosis that affects mammals, including humans. Essential to Brucella virulence is its ability to survive and replicate inside host ...
