dc.contributor.author | Mora, Ana María | |
dc.contributor.author | van Wendel de Joode, Berna | |
dc.contributor.author | Mergler, Donna | |
dc.contributor.author | Córdoba, Leonel | |
dc.contributor.author | Cano, Camilo | |
dc.contributor.author | Quesada, Rosario | |
dc.contributor.author | Smith, Donald R | |
dc.contributor.author | Lindh, Christian H | |
dc.contributor.author | Bradman, Asa | |
dc.contributor.author | Eskenazi, Brenda | |
dc.contributor.author | Menezes-Filho, José A. | |
dc.contributor.author | Lundh, Thomas | |
dc.date.accessioned | 2016-10-13T21:27:59Z | |
dc.date.available | 2016-10-13T21:27:59Z | |
dc.date.issued | 2014-03 | |
dc.identifier.uri | http://hdl.handle.net/11056/13216 | |
dc.description.abstract | Manganese (Mn), an essential nutrient, is a neurotoxicant at high concentrations. We measured Mn concentrations in
repeated blood and hair samples collected from 449 pregnant women
living near banana plantations with extensive aerial spraying of Mncontaining fungicide mancozeb in Costa Rica, and examined
environmental and lifestyle factors associated with these biomarkers.
Mean blood Mn and geometric mean hair Mn concentrations were
24.4 μg/L (8.9−56.3) and 1.8 μg/g (0.05−53.3), respectively. Blood
Mn concentrations were positively associated with gestational age at
sampling (β = 0.2; 95% CI: 0.1 to 0.2), number of household members
(β = 0.4; 95% CI: 0.1 to 0.6), and living in a house made of permeable
and difficult-to-clean materials (β = 2.6; 95% CI: 1.3 to 4.0); and
inversely related to smoking (β = −3.1; 95% CI: −5.8 to −0.3). Hair
Mn concentrations were inversely associated with gestational age at
sampling (% change = 0.8; 95% CI: −1.6 to 0.0); and positively associated with living within 50 m of a plantation (% change =
42.1; 95% CI: 14.2 to 76.9) and Mn concentrations in drinking water (% change = 17.5; 95% CI: 12.2 to 22.8). Our findings
suggest that pregnant women living near banana plantations aerially sprayed with mancozeb may be environmentally exposed to
Mn. | |
dc.description.abstract | El manganeso (Mn), un nutriente esencial, es un neurotóxico en altas concentraciones. Medimos las concentraciones de Mn en
muestras repetidas de sangre y cabello recogidas de 449 mujeres embarazadas que vivían cerca de plantaciones de plátanos con una amplia fumigación aérea de Mn que contenía el fungicida mancozeb en Costa Rica, y examinó
factores ambientales y de estilo de vida asociados a estos biomarcadores.
La media de las concentraciones de Mn en sangre y la media geométrica de Mn en pelo fueron
24,4 μg/L (8,9-56,3) y 1,8 μg/g (0,05-53,3), respectivamente. Sangre
Las concentraciones de Mn se asociaron positivamente con la edad gestacional a
muestreo (β = 0,2; IC 95%: 0,1 a 0,2), número de miembros del hogar
(β = 0.4; 95% CI: 0.1 a 0.6), y viviendo en una casa hecha de permeable
y materiales difíciles de limpiar (β = 2.6; 95% CI: 1.3 a 4.0); y
inversamente relacionado con el tabaquismo (β = -3.1; 95% CI: -5.8 a -0.3). Cabello
Las concentraciones de Mn estaban inversamente asociadas con la edad gestacional a
de muestreo (cambio porcentual = 0,8; IC del 95%: -1,6 a 0,0); y se asocian positivamente con vivir a menos de 50 m de una plantación (cambio porcentual =
42,1; IC del 95%: 14,2 a 76,9) y las concentraciones de Mn en el agua potable (cambio porcentual = 17,5; IC del 95%: 12,2 a 22,8). Nuestros hallazgos
sugieren que las mujeres embarazadas que viven cerca de las plantaciones de plátanos rociadas desde el aire con mancozeb pueden estar expuestas a
Mn. | |
dc.description.sponsorship | Universidad Nacional, Costa Rica | |
dc.description.sponsorship | University of California, Berkeley,
1995 University Ave, Suite 265, Berkeley, California 94704, United States | |
dc.description.sponsorship | Universitédu Quebec a Montreal | |
dc.description.sponsorship | University of California, Santa Cruz, 1156 High Street, Santa Cruz, California 95064, United States | |
dc.description.sponsorship | Federal University of Bahia, Av. Barao de Jeremoabo s/n Campus Universita ̃ rio de ́
Ondina, 40170-115 Salvador, Bahia, Brazil | |
dc.description.sponsorship | Lund University, SE-221 85 Lund, Sweden | |
dc.language.iso | en | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.rights | Acceso abierto | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Environmental Science & Technology vol.48 no.6 3467-3476 2014 | |
dc.subject | ISA | |
dc.subject | PRODUCTOS QUÍMICOS | |
dc.subject | PROGRAMA INFANTES Y SALUD AMBIENTAL | |
dc.subject | RIESGOS PARA LA SALUD | |
dc.subject | SALUD PÚBLICA | |
dc.subject | TOXICOLOGÍA | |
dc.subject | CHEMICAL PRODUCTS | |
dc.subject | HEALTH RISKS | |
dc.subject | PUBLIC HEALTH | |
dc.subject | TOXICOLOGY | |
dc.title | Blood and hair manganese concentrations in pregnant women from the infants' environmental health study (ISA) in Costa Rica | es_ES |
dc.type | http://purl.org/coar/resource_type/c_6501 | es_ES |
dc.description.procedence | Instituto Regional de Estudios en Sustancias Tóxicas, Universidad Nacional, Costa Rica | |
dc.description.procedence | Center for Environmental Research and Children’s Health (CERCH), School of Public Health, University of California | |
dc.description.procedence | Centre de Recherche Interdisciplinaire sur la Biologie, la Sante, la Socie ́ té ́et l′Environnement (CINBIOSE), Universitédu Quebec a ́ ̀
Montreal | |
dc.description.procedence | Microbiology and Environmental Toxicology, University of California | |
dc.description.procedence | Laboratory of Toxicology, College of Pharmacy, Federal University of Bahia | |
dc.description.procedence | Division of Occupational and Environmental Medicine, Institute of Laboratory Medicine, Lund University | |
dc.identifier.doi | dx.doi.org/10.1021/es404279r | |