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Multidrug-resistant Clostridium Difficile Ribotypes 078 and 014/5-FLI01 in Piglets From Costa Rica
(Elsevier, 2018-11-08)
Though an overlap of Clostridium difficile PCR ribotypes (RT) in humans and animals has been noted -particularly in piglets-information regarding C. difficile isolates from swine is scarce in Latin America. A characterization ...
Emergence of an outbreak-associated Clostridium difficile variant with increased virulence
(Journal of Clinical Microbiology, 2015-04-23)
The prevalence of Clostridium difficile infections has increased due to the emergence of epidemic variants from diverse genetic lineages. Here we describe the emergence of a novel variant during an outbreak in a Costa Rican ...
Analysis of TcdB proteins within the hypervirulent clade 2 reveals an impact of RhoA glucosylation on Clostridium difficile proinflammatory activities
(Infection and Immunity, 2016-03)
Clostridium difficile strains within the hypervirulent clade 2 are responsible for nosocomial outbreaks worldwide. The increased pathogenic potential of these strains has been attributed to several factors but is still ...
In vivo animal models confrm an increased virulence potential and pathogenicity of the NAP1/RT027/ST01 genotype within the Clostridium difcile MLST Clade 2
(BioMed Central, 2020-09-22)
Background: Based on MLST analyses the global population of C. difcile is distributed in eight clades, of which
Clade 2 includes the “hypervirulent” NAP1/RT027/ST01 strain along with various unexplored sequence types ...