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Now showing items 21-30 of 36
A Sinorhizobium meliloti and Agrobacterium tumefaciens ExoR ortholog is not crucial for Brucella abortus virulence
(PLOS ONE, 2021-08-13)
Brucella is a facultative extracellular-intracellular pathogen that belongs to the Alphaproteo-
bacteria class. Precise sensing of environmental changes and a proper response mediated
by a gene expression regulatory ...
Canine brucellosis in Costa Rica reveals widespread Brucella canis infection and the recent introduction of foreign strains
(Elsevier, 2021-04-16)
Brucellosis is a prevalent disease in Costa Rica (CR), with an increasing number of human infections. Close to half of homes in CR have one or more dogs, corresponding to ∼1.4 million canines, most of them in the Central ...
Brucella abortus S19 GFP-tagged vaccine allows the serological identification of vaccinated cattle
(PLOS ONE, 2021-11-22)
Bovine brucellosis induces abortion in cows, produces important economic losses, and
causes a widely distributed zoonosis. Its eradication was achieved in several countries after
sustained vaccination with the live ...
Platelet depletion does not alter the course of Brucella abortus infection in vivo
(Elsevier, 2022-02-23)
Brucellosis is a bacterial disease of animals and a zoonotic infection. Thrombocytopenia is a common outcome in
long-lasting brucellosis in humans. Likewise, ex vivo experiments have shown that platelets may play a role ...
Determination of streptomycin and doxycycline using LC/MS towards an effective treatment against an experimental Brucella abortus infection in mice
(Elsevier B.V, 2022-02-25)
Herein we described a versatile liquid chromatographic method for detection and quantification of the total
levels of two antimicrobials [i.e., streptomycin (STM) and doxycycline (DOX)], in mice plasma and selected
tissues, ...
A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence
(Blackwell Science, 1998-04-08)
Two mutants showing increased sensitivity to polycations and surfactants were obtained by transposon mutagenesis of virulent Brucella abortus 2308 Nal(r). These mutants showed no obvious in vitro growth defects and produced ...
Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum
(The Rockefeller University Press, 2003-01-18)
The intracellular pathogen Brucella is the causative agent of brucellosis, a worldwide zoonosis
that affects mammals, including humans. Essential to Brucella virulence is its ability to survive and
replicate inside host ...
Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes
(American Society for Microbiology, 1988-09-01)
Brucella abortus is an intracellular pathogen that replicates within a membrane-bounded compartment. In
this study, we have examined the intracellular pathway of the virulent B. abortus strain 2308 (S2308) and the
attenuated ...
Brucella abortus lipopolysaccharide in murine peritoneal macrophages acts as a down-regulator of T cell activation
(The American Association of Immunologists, Inc., 2000)
Macrophages play a central role in host immune responses against pathogens by acting as both professional phagocytic cells and
as fully competent APCs. We report here that the LPS from the facultative intracellular ...
Brucella-Salmonella lipopolysaccharide chimeras are less permeable to hydrophobic probes and more sensitive to cationic peptides and EDTA than are their native Brucella sp. counterparts
(American Society for Microbiology, 1996-08-12)
A rough (R) Brucella abortus 45/20 mutant was more sensitive to the bactericidal activity of polymyxin B and lactoferricin B than was its smooth (S) counterpart but considerably more resistant than Salmonella montevideo. ...