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Depletion of complement enhances the clearance of Brucella abortus in mice
(American Society for Microbiology, 2018-08-06)
Brucellosis is a bacterial disease of animals and humans. Brucella abortus barely activates the innate immune system at the onset of infection, and this bacterium is resistant to the microbicidal action of complement. Since ...
Brucella abortus strain 2308 Wisconsin genome: Importance of the definition of reference strains
(Frontiers in Microbiology, 2016-09-29)
La brucelosis es una enfermedad infecciosa bacteriana que afecta a una amplia gama de mamíferos y una zoonosis desatendida causada por especies del género genéticamente homogéneo Brucella. Como en la mayoría de los estudios ...
Brucella abortus induces the premature death of human neutrophils through the action of Its lipopolysaccharide
(PLoS Pathogens, 2015-05-06)
Most bacterial infections induce the activation of polymorphonuclear neutrophils (PMNs), enhance their microbicidal function, and promote the survival of these leukocytes for protracted periods of time. Brucella abortus ...
Neutrophils dampen adaptive immunity in Brucellosis
(American Society For Microbiology, 2019-04-23)
Brucella organisms are intracellular stealth pathogens of animals and humans. The bacteria overcome the assault of innate immunity at early stages of an infection. Removal of polymorphonuclear neutrophils (PMNs) at the ...
Neutrophils as Trojan Horse vehicles for Brucella abortus macrophage infection
(Universidad Nacional, Costa Rica, 2019-05-07)
Brucella abortus is a stealthy intracellular bacterial pathogen of animals and humans. This bacterium promotes the premature cell death of neutrophils (PMN) and resists the killing action of these leukocytes. B. abortus-infected ...
Persistence of Brucella abortus in the bone marrow of infected mice
(Journal of Immunology Research, 2018-12-03)
Brucellosis is a zoonotic bacterial infection that may persist for long periods causing relapses in antibiotic-treated patients. The ability of Brucella to develop chronic infections is linked to their capacity to invade ...
N-formyl-perosamine surface homopolysaccharides hinder the recognition of Brucella abortus by mouse neutrophils
(Universidad Nacional, Costa Rica, 2016-06)
Brucella abortus is an intracellular pathogen of monocytes, macrophages, dendritic cells, and placental trophoblasts. This bacterium causes a chronic disease in bovines and in humans. In these hosts, the bacterium also ...
Neutrophils exert a suppressive effect on Th1 responses to intracellular pathogen Brucella abortus
(PLoS Pathogens, 2013-02-14)
Polymorphonuclear neutrophils (PMNs) are the first line of defense against microbial pathogens. In addition to their role in innate immunity, PMNs may also regulate events related to adaptive immunity. To investigate the ...
Epidemiology of bovine brucellosis in Costa Rica: Lessons learned from failures in the control of the disease
(PLOS ONE, 2017-08-10)
Brucellosis, caused by Brucella abortus is a major disease of cattle and a zoonosis. In order
to estimate the bovine brucellosis prevalence in Costa Rica (CR), a total 765 herds (13078
bovines) from six regions of CR ...
Brucella abortus senses the intracellular environment through the BvrR/Bvrs two-component system, which allows B. abortus to adapt to its replicative nich
(American Society for Microbiology., 2018-01-16)
Brucella abortus is a facultative extracellular-intracellular pathogen belonging to a group of Alphaproteobacteria that establishes close interactions with animal cells. This bacterium enters host cells in a membrane-bound ...